We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Intellectual property in biotechnology invention provides important incentives for research and development leading to advances in genetic tests and treatments. However, there have been numerous concerns raised regarding the negative effect patents on gene sequences and their practical applications may have on clinical research and the availability of new medical tests and procedures. One concern is that licensing policies attempting to capture for the benefit of the licensor valuable rights to downstream research results and products may increase the financial risks (...) and cliniinish potential payoffs of — and therefore motivation for — performing downstream research and development. In addition, very broad patent claims allowed by the U.S. Patent and Trademark Office, the sheer growth in patents claiming genetic sequences, and threats of overlapping patents create a veritable minefield for researchers in both academia and industry. The concern is that research may be stifled because of the high cost and hassle of negotiating access. (shrink)

Intellectual property in biotechnology invention provides important incentives for research and development leading to advances in genetic tests and treatments. However, there have been numerous concerns raised regarding the negative effect patents on gene sequences and their practical applications may have on clinical research and the availability of new medical tests and procedures. One concern is that licensing policies attempting to capture for the benefit of the licensor valuable rights to downstream research results and products may increase the financial risks (...) and cliniinish potential payoffs of — and therefore motivation for — performing downstream research and development. In addition, very broad patent claims allowed by the U.S. Patent and Trademark Office, the sheer growth in patents claiming genetic sequences, and threats of overlapping patents create a veritable minefield for researchers in both academia and industry. The concern is that research may be stifled because of the high cost and hassle of negotiating access. (shrink)

This article investigates a theory of type assignment (assigning types to lambda terms) called ETA which is intermediate in strength between the simple theory of type assignment and strong polymorphic theories like Girard’s F (Proofs and types. Cambridge University Press, Cambridge, 1989). It is like the simple theory and unlike F in that the typability and type-checking problems are solvable with respect to ETA. This is proved in the article along with three other main results: (1) all primitive recursive functionals (...) of finite type are representable in ETA; (2) every term typable in ETA has a unique normal form; (3) there is a function defined by ${{\varepsilon}_0}$ -recursion which takes every typable term to a natural number which is an upper bound to the lengths of all βη-reduction sequences starting with that term. (shrink)

This article develops how wider understandings of time may help inform managers’ communication decisions. Using Peter F. Drucker as an initial touchstone—but going much deeper—the article employs an applied liberal arts methodology to establish a time-minded attitude toward communication. Applying perspectives from both classical philosophy (specifically Plato and Aristotle) as well as twentieth century rhetoricians (specifically Richard Weaver, James Kinneavy, and Walter Beale), this article celebrates both physical and metaphysical structures of reality. To this end, it proposes a theoretical (...) equation to help calibrate communication management under a more holistic banner. The equation acknowledges the typical appropriateness of occasion-directed communication (kairos); however, it also distinctively acknowledges the grand fabric of temporal reality (chronos). The output of this equation can be understood as the “chronos principle.” The article concludes that a more complete understanding of time-mindedness can elevate empathy, foster respect, and assist social relationality within any given organization’s communication culture. (shrink)

In a survey of information theory and some of its implications, Warren Weaver has proposed a distinction between engineering noise and semantic noise. Ordinary Spanish usage reflects this distinction quite neatly. If A speaks to B and B responds with no entiendo, it means ‘I have not heard your words, because of interfering sound or lack of attention; please transmit the same message again’; if he responds with no comprendo, it means ‘I heard you all right, but what I (...) heard doesn't make sense; please paraphrase or explain.’ Channel noise, thus, is the responsible factor when that which leaves a transmitter is not that which reaches the receiver; semantic noise is a discrepancy between the codes used by transmitter and receiver. (shrink)

This interdisciplinary and ecumenical collection of essays honors the transformative work of Margaret A. Farley, Gilbert L. Stark Professor of Christian Ethics at Yale Divinity School, using it as a starting point for reflection on the contribution of feminist method to theology and ethics. Through a variety of perspectives, contributors show that by resisting classical oppositions between “interpersonal” and “social” ethics and by insisting that social, economic, and political realities be taken seriously in considerations of justice, feminist concerns challenge the (...) very categories of Christian ethics. With essays ranging from sexual ethics to human rights, medical ethics to freedom, _A Just and True Love_ offers a broad perspective on the last twenty-five years of feminist innovation in Christian ethics and a glimpse of its global future, particularly in continents such as Africa. “This book brings together a number of the most prominent thinkers in Christian theology and ethics today in a justly deserved tribute to the work and influence of Margaret Farley. The essays explicitly acknowledge and engage Farley in various degrees; one comes away appreciating both the integrity of her work and its versatility.” —_Darlene Fozard Weaver, Villanova University _ “Inevitably while listening to or reading Margaret Farley, we find her refrain, ‘I want to ask all over again.’ Reexamining, reframing, and rethinking is Farley’s method of engaging anew human experience and relationality. The authors of these essays capture that method as they reconsider feminism and sexuality, love and freedom, justice and truth, contraception and women’s rights. Like her own work, they reset the ethical agenda to recapture a more loving truth. A very successful collection for a most admired colleague. Ryan and Linnane are to be congratulated!” —_James F. Keenan, S.J., Boston College_ “In_ A Just and True Love,_ a host of distinguished scholars consider fundamental themes of feminist theological ethics and their significance for global justice, the meaning of Christian love, creative casuistry, and truthful life in the Church. I can imagine no higher praise than to affirm that these authors have succeeded marvelously in doing exactly what they set out to do: to produce a volume worthy of the theological work and wisdom of Margaret Farley.” —_William Werpehowski, Villanova University_. (shrink)

Many philosophers hypothesize that our concept of personal identity is partly constituted by the one-person-one-place rule, which states that a person can only be in one place at a time. This hypothesis has been assumed by the most influential contemporary work on personal identity. In this paper, we report a series of studies testing whether the hypothesis is true. In these studies, people consistently judged that the same person existed in two different places at the same time. This result undermines (...) some widely held philosophical assumptions, supports others, and fits well with recent discoveries on identity judgments about inanimate objects and non-human animals. (shrink)

The article investigates a system of polymorphically typed combinatory logic which is equivalent to Gödel’s T. A notion of (strong) reduction is defined over terms of this system and it is proved that the class of well-formed terms is closed under both bracket abstraction and reduction. The main new result is that the number of contractions needed to reduce a term to normal form is computed by an ε 0-recursive function. The ordinal assignments used to obtain this result are also (...) used to prove that the system under consideration is indeed equivalent to Gödel’s T. It is hoped that the methods used here can be extended so as to obtain similar results for stronger systems of polymorphically typed combinatory terms. An interesting corollary of such results is that they yield ordinally informative proofs of normalizability for sub-systems of second-order intuitionist logic, in natural deduction style. (shrink)

In an attempt to improve upon Alexander Pruss’s work (The principle of sufficient reason: A reassessment, pp. 240–248, 2006), I (Weaver, Synthese 184(3):299–317, 2012) have argued that if all purely contingent events could be caused and something like a Lewisian analysis of causation is true (per, Lewis’s, Causation as influence, reprinted in: Collins, Hall and paul. Causation and counterfactuals, 2004), then all purely contingent events have causes. I dubbed the derivation of the universality of causation the “Lewisian argument”. The (...) Lewisian argument assumed not a few controversial metaphysical theses, particularly essentialism, an incommunicable-property view of essences (per Plantinga’s, Actualism and possible worlds, reprinted in: Davidson (ed.) Essays in the metaphysics of modality, 2003), and the idea that counterfactual dependence is necessary for causation. There are, of course, substantial objections to such theses. While I think a fight against objections to the Lewisian argument can be won, I develop, in what follows, a much more intuitive argument for the universality of causation which takes as its inspiration a result from Frederic B. Fitch’s work (J Symb Logic 28(2):135–142, 1963) [with credit to who we now know was Alonzo church’s, Referee Reports on Fitch’s Definition of value, in: (Salerno (ed.), New essays on the knowability paradox, 2009)] that if all truths are such that they are knowable, then (counter-intuitively) all truths are known. The resulting Church–Fitch proof for the universality of causation is preferable to the Lewisian argument since it rests upon far weaker formal and metaphysical assumptions than those of the Lewisian argument. (shrink)

Ethical decision theory may not be sufficiently well developed to furnish reliable guidelines to people involved in complex decision making that involves conflict between ethical considerations and business imperatives such as making a profit. In conditions of ethical uncertainty hindsight bias may occur, and this study reports on an exploration of hindsight bias effects among participants in continuing education in business programmes. Perceptions of business ethics were found to differ among groups within the sample depending on what they thought had (...) been the outcome of the ethical decision concerned. (shrink)

Contemporary Roman Catholic ethics endeavors to take sin seriously by offering theologies of sin that emphasize it as a force and as a basic, personal orientation. Such efforts rightly counter the Catholic tradition's earlier reduction of sin to sins, and sins to external acts and moral culpability. But perhaps they go too far in this regard. By engaging Charles Curran, this study argues that inattention to sins undermines the theological referent of sin as a discourse that concerns more than moral (...) culpability, obscures God as the source of freedom and value, and neglects the way in which acts express and sustain sin and fashion a personal orientation. Drawing on the work of Jean Porter, the essay shows that attention to sins highlights the historicity, particularity, and provisionality of human acts because of the theological referent and analogical character of sin and sins. (shrink)

The chorion genes of Drosophila are amplified in response to developmental signals in the follicle cells of the ovary prior to their transcription. Their expression is regulated both temporally and spatially within this tissue. They thus serve as models both for the regulation of DNA replication and of developmental transcription. The regulatory elements for DNA amplification have been delineated. Their analysis reveals that amplification is mediated by several regulatory regions and initiates at defined origins within the chorion cluster. Proteins involved (...) in amplification are being identified both by mutations affecting amplification and by DNA binding studies. Regulatory elements for temporal as well as spatial control of chorion gene, expression have been characterized, and two candidate transcription factor genes have been cloned. (shrink)

This article tackles the current deficit in the supply of cadaveric organs by addressing the family veto in organ donation. The authors believe that the family veto matters—ethically as well as practically—and that policies that completely disregard the views of the family in this decision are likely to be counterproductive. Instead, this paper proposes to engage directly with the most important reasons why families often object to the removal of the organs of a loved one who has signed up to (...) the donor registry—notably a failure to understand fully and deliberate on the information and a reluctance to deal with this sort of decision at an emotionally distressing time. To accommodate these concerns it is proposed to separate radically the process of information, deliberation and agreement about the harvesting of a potential donor's organs from the event of death and bereavement through a scheme of advance commitment. This paper briefly sets out the proposal and discusses in some detail its design as well as what is believed to be the main advantages compared with the leading alternatives. (shrink)

Appearing in English for the first time, Schelling’s 1842 lectures develop the idea that many philosophical concepts are born of religious-mythological notions.

After an introduction which demonstrates the failure of the equational analogue of Beth?s definability theorem, the first two sections of this paper are devoted to an elementary exposition of a proof that a functional constant is equationally definable in an equational theory iff every model of the set of those consequences of the theory that do not contain the functional constant is uniquely extendible to a model of the theory itself.Sections three, four and five are devoted to applications and extensions (...) of this result.Topics considered here include equational definability in first order logic, an extended notion of definability in equational logic and the synonymy of equational theories.The final two sections briefly review some of the history of equational logic. (shrink)

The main purpose of this article is to argue that Crispin Wright and Bob Hale have not succeeded in overcoming the well-known ‘Julius Caesar objection’ to their proposed definition of the phrase ‘the number of’. It is hoped that the article will also help to clarify what would actually be needed in order to overcome this objection.

Pacifism is routinely criticized as sectarian, incoherent, and preoccupied with moral purity at the expense of responsibility. The author contends that the pacifism of John Howard Yoder is vulnerable to none of these charges and defends this claim by establishing parallels between Yoder's analysis of killing and Augustine's analysis of lying. Although, within the terms of his own argument, Augustine's rejection of all lying as unjust is consistent with his condoning of some killing as just, the author shows that given (...) a different conception of the defining characteristic of God , Augustine's theological argument against lying would become an argument against violence. The author therefore suggests that Yoder's rejection of killing is no more sectarian, incoherent, or irresponsible than Augustine's rejection of lying. (shrink)

We argue that there exists a necessary causally potent being. We then argue that that being is God.

This paper starts with one of Chalmers’ basic points: first-hand experience is an irreducible field of phenomena. I claim there is no ‘theoretical fix’ or ‘extra ingredient’ in nature that can possibly bridge this gap. Instead, the field of conscious phenomena requires a rigorous method and an explicit pragmatics for its exploration and analysis. My proposed approach, inspired by the style of inquiry of phenomenology, I have called neurophenomenology. It seeks articulations by mutual constraints between phenomena present in experience and (...) the correlative field of phenomena established by the cognitive sciences. It needs to expand into a widening research community in which the method is cultivated further. (shrink)

William R. Stirton; III*—The Logical Status of ‘Exists’, Proceedings of the Aristotelian Society, Volume 95, Issue 1, 1 June 1995, Pages 37–50, https://doi.org/.

William R. Stirton; III*—The Logical Status of ‘Exists’, Proceedings of the Aristotelian Society, Volume 95, Issue 1, 1 June 1995, Pages 37–50, https://doi.org/.

The article begins by distinguishing a number of theses which, in the past, have sometimes been lumped together under the heading of 'anti-realism'. One of the theses is that there is something wrong with truth-conditional theories of meaning (what a truth-conditional theory of meaning is a matter discussed at some length), another is what I take to be the central thesis of anti-realism, that all truths are knowable. Several writers on the subject, such as Wright and Prawitz, have defended the (...) latter thesis while jettisoning the former. I argue that this position is exactly the wrong way around. Given the 'meaning is use' principle, which is also called the 'manifestation requirement', a very powerful case can be made that true theory of meaning cannot be truth-conditional. But I argue that, given the current state of our logical knowledge, there is no good reason for concluding from this that a true theory of meaning must be of the 'verificationist' type, as Dummett seems to think, and still less for thinking that anti-realism follows. I end by examining theories of meaning against Dummett's criticisms. (shrink)

Debates over physician-assisted suicide comprise a small portion of broader culture wars. Their role in the culture wars obscures an under-acknowledged consensus between those who support PAS and those who oppose it. Drawing insights from personalism, this essay situates PAS within larger moral obligations of solidarity with the dying and their caregivers. The contributions of Roman Catholic personalism relocate debates over PAS and allow us to harness shared moral impulses.